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Recent Publications

  1. Wu Y, Chen R, Zhao X, Li A, Li G, Zhou J. JWA regulates chronic morphine dependence via the delta opioid receptor. Biochem. Biophys. Res. Commun. 409:520-525, 2011.
  2. Chen G, Cheng Y, Zhang Z, Martinka M, Li G. Prognostic significance of cytoplasmic p27 expression in human melanoma. Cancer Epidemiology, Biomarkers & Prevention 20:2212-2221, 2011.
  3. Jafarnejad SM, Li G. Regulation of p53 by ING family members in suppression of tumor initiation and progression. Cancer & Metast Rev. (in press)
  4. Cheng Y, Li G. Role of the ubiquitin ligase Fbw7 in cancer progression. Cancer & Metast Rev. (in press)
  5. Chen G, Cheng Y, Zhang Z, Martinka M, Li G. Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival. PLoS ONE, 6(2):e17578.
  6. Wong RPC, Lin H, Khosravi S, Jafarnejad SM, Chen D, Li G. Tumour suppressor ING1b maintains genomic stability upon replication stress. Nucleic Acids Res. 39:3632-3642, 2011.
  7. Wani A, Jafarnejad SM, Zhou J, Li G. Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway. Oncogene. 30:2778-2788, 2011.
  8. Piche B, Khosravi S, Martinka M, Ho V, Li G. CDH22 expression is reduced in metastatic melanoma. Am. J. Cancer Res. 1:233-239, 2011.
  9. Aguissa-Touré A, Wong RPC, Li G. The ING family Proteins: From structure to function. Cell. Mol. Life Sci. 68:45-54, 2010.
  10. Jafarnejad SM, Wani A, Martinka M, Li G. Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion. Am. J. Pathol. 277:2741-2752, 2010.
  11. Li G, Piche B. ING2 in cell cycle regulation. Cell Cycle. 9:3846, 2010.
  12. Li J, Cheng Y, Tai D, Martinka M, Welch D, Li G. Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis. Oncogene. 30:896-906, 2011.
  13. Bai J, Zhou Y, Chen G, Zeng J, Ding J, Terry J, Tan Y, Zhou J, Li G. Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. Human Pathol. 42:375-383, 2011.
  14. Li J, Zhang Z, Li G. Patient outcome prediction by multiple biomarkers in human melanoma: A clinicopathologic study of 118 cases. Exp. Ther. Med. 2: 131-135, 2011.
  15. Li J, Li G. Cell cycle regulator ING4 is a suppressor of melanoma angiogenesis that is regulated by the metastasis suppressor BRMS1. Cancer Res. 70:10445-53, 2010.
  16. Zhang Z, Chen G, Cheng Y, Martinka M, Li G. Prognostic significance of RUNX3 expression in melanoma. Cancer. 117:2719-2727, 2011.
  17. Piche B, Li G. Inhibitor of growth tumor suppressors in cancer progression. Cell. Mol. Life Sci. 67:1987-1999, 2010.
  18. Garate M, Wani AA, Li G. The NAD(P)H:Quinone Oxidoreductase1 induces cell cycle progression and proliferation of melanoma cells. Free Radical Biol. & Med. 48:1601-1609, 2010.
  19. Chen G, Li G. Cul1 expression promotes melanoma cell proliferation through regulating p27 expression. Int. J. Oncol. 37:1339-1344, 2010.
  20. Lin H, Wong RPC, Martinka M, Li G. BRG1 expression is increased in human cutaneous melanoma. Br. J. Dermatol. 163: 502-510, 2010.
  21. Wang Y, Jiang H, Dai D, Su M, Martinka M, Brasher P, Zhang Y, McLean D, Zhang J, Ip W, Li G, Zhang X, Zhou Y. Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma. Pigment Cell & Melanoma Res. 23:575-578, 2010.
  22. Chen G, Cheng Y, Martinka M, Li G. Cul1 expression is increased in early stages of human melanoma. Pigment Cell & Melanoma Res. 23:572-574, 2010.
  23. Chen G, Wang Y, Garate M, Zhou J, Li G. The tumor suppressor ING3 is degraded by the ubiquitin-proteosome system. Oncogene, 29: 1498-1508, 2010.
  24. Bai J, Zhang J, Wu J, Shen L, Zeng J, Ding J, Wu Y, Gong Z, Li A, Xu S, Zhou J, Li G. JWA regulates melanoma metastasis via integrin avb3 signaling. Oncogene, 29:1227-1237, 2010.
  25. Cheng Y, Li J, Martinka M, Li G. The expression of NAD(P)H:quinone oxidoreductase 1  is increased along with NF-κB p105/ p50 in human cutaneous melanomas. Oncol. Rep. 23:973-979, 2010.
  26. Lin LH, Wong RPC, Martinka M, Li G. Loss of SNF5 Expression Correlates with Poor Patient Survival in Melanoma. Clin. Cancer Res. 15(20):6404-6411, 2009.
  27. Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, Jia Z, Li Q, Yao JC, Xie K. Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of Chinese patients with gastric cancer. Clin. Cancer Res. 15:1821-1829, 2009.
  28. Li J, Wang Y, Wong RPC, Li G. The role of ING tumor suppressors in UV stress response and melanoma progression. Curr Drug Targets 10:455-464, 2009.
  29. Wang S, Chen R, Gong Z, Liu Y, Li A, Li G, Zhou J. JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative stress-induced DNA single-strand breaks. Nucleic Acids Res., 37:1936-1950, 2009.
  30. Karst AM, Gao K, Nelson CC, Li G. Nuclear factor kappaB subunit p50 promotes melanoma angiogenesis via upregulating interleukin-6 expression. Int. J. Cancer 124:494-501, 2009.
  31. Li J, Martinka M, Li G. Role of ING4 in human melanoma cell migration, invasion, and patient survival. Carcinogenesis 29:1373-1379, 2008.
  32. Garate M, Wong R, Campos EI, Wang Y, Li G. NQO1 inhibits the proteasomal degradation of the tumor suppressor p33ING1b. EMBO Rep. 9:576-581, 2008.
  33. Gao K, Lockwood WW, Li J, Lam W, Li G. Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells. Int. J. Oncol. 32:1343-1349, 2008.
  34. Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J. Mol. Biol. 380:303-312, 2008.
  35. Wong RPC, Khosravi S, Martinka M, Li G. Mcl-1 expression is overexpressed in dysplastic nevi and melanoma. Oncol. Rep. 19:933-937, 2008.
  36. Liang Z, Wong RPC, Li LH, Jiang H, Xiao H, Li G. Development of pan-specific antibody against trimethyllysine for protein research. Proteome Sci. 2008 Jan 22 (Epub); 6:2. 
  37. Dai DL, Wang Y, Liu M, Martinka M, Li G. Reduced Bim expression in human cutaneous melanomas. J. Invest. Dermatol. 2008 Feb; 128:403-407.
  38. Garate M, Campos EI, Bush JA, Xiao H, Li G. Phosphorylation of the tumor suppressor p33ING1b at Ser126 influences its protein stability and cell proliferation. FASEB J. 2007 Nov; 21:3705-3716.
  39. Wang Y, Dai DL, Martinka M, Li G. Prognostic significance of ING3 subcellular localization in human cutaneous melanoma. Clin. Cancer Res. 2007 Jun 15; 13: 4111-4116.

  40. Wong RPC, Ng P, Dedhar S, Li G. The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth. Mol. Cancer Ther. 2007 Jun; 6:1692-1700.

  41. Cheung KJ Jr., Li G, Urban TA, Goldberg JB, Lu F, Burn JL. Pilus-mediated epithelial cell death in response to infection with Burkholderia cenocepacia. Microbes and Infection 2007 Jun 9; 9:829-837.

  42. Kuo WH, Wang Y, Wong R, Campos EI, Li G. The ING1b protein facilitates accessibility to damaged nucleosomal DNA. Exp. Cell Res. 2007 May 1; 313:1628-1638.
  43. Karst AM, Li G. BH3-only proteins in tumorigenesis and malignant melanoma. Cell Mol Life Sci. 2007 Feb;64(3):318-30.
  44. Karst AM, Dai DL, Cheng JQ, Li G. Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer Res. 2006 Sep 15;66(18):9221-6.
  45. Gao K, Dai DL, Martinka M, Li G. Prognostic Significance of Nuclear Factor-{kappa}B p105/p50 in Human Melanoma and Its Role in Cell Migration. Cancer Res. 2006 Sep 1;66(17):8382-8.
  46. Wang Y, Wang J, Li G. Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. FEBS Lett. 2006 Jul 10;580(16):3787-93.
  47. Tang L, Dai DL, Su M, Martinka M, Li G. Zhou Y. Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Clin Cancer Res. 2006 Jun 15;12(12):3716-22.
  48. Wang Y, Li G. ING3 promotes UV-induced apoptosis via Fas/caspase-8 pathway in melanoma cells. J Biol Chem. 2006 Apr 28;281(17):11887-93.
  49. Wang J, Chin MY, Li G. The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer Res. 2006 Feb 15;66(4):1906-11.
  50. Lu F, Dai DL, Martinka M, Ho V, Li G. Nuclear ING2 expression is reduced in human cutaneous melanomas. Br J Cancer. 2006 Jul 3;95(1):80-6.
  51. Ho CK, Li G. Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis.  Br. J. Dermatol. 153:900-910, 2005.
  52. Zhou Y, Dai DL, Martinka M, Su M, Zhang Y, Campos EI, Dorocicz I, Tang L, Nelson C, Ho V, Li G. Osteopontin expression correlates with melanoma invasion and promotes cell growth. J. Invest. Dermatol. 124:1044-1052, 2005.
  53. Dai DL, Martinka M, Li G. Prognostic significance of activated Akt expression in melanoma: A clinicopathological study of 292 cases. J. Clin. Oncol. 23:1473-1482, 2005. (Highlighted in Nature Clinical Practice Oncology Vol. 2, p280)
  54. Chin MY, Ng KCP, Li G. The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. Exp. Cell Res. 304:531-543, 2005.
  55. Karst AM, Dai DL, Martinka M, Li G. PUMA expression is significantly reduced in human cutaneous melanomas. Oncogene 24:1111-1116, 2005.
  56. Qiang L, Campos EI, Xiao H, Ho VC, Li G. Development of a pan-specific, affinity-purified anti-acetylated lysine antibody for detection, identification, isolation and intracellular localization of acetylated protein. J. Immunoassay & Immunochem. 26: 13-24, 2005.
  57. Jia W, Bu X, Philips D, Yan H, Liu G, Chen X, Bush JA, Li G. Rh2, a compound extracted from ginseng, hypersensitzes multidrug-resistant tumor cells to chemotherapy. Can. J. Physiol. Pharmacol. 82: 431-437, 2004.
  58. Ng KP, Campos EI, Martinka M, Li G. XAF1 expression is significantly reduced in human malignant melanoma. J. Invest. Dermatol. 123:1127-1134, 2004.
  59. Campos EI, Chin MY, Kuo WH, Li G. Biological functions of the ING family tumor suppressors. Cell. Mol. Life Sci. 61:2597-2613, 2004.
  60. Dai DL, Martinka M, Bush JA, Li G. Reduced Apaf-1 expression in human cutaneous melanoma. Br. J. Cancer 91:1089-1095, 2004.
  61. Bush JA, Li G. Current advances in metastatic melanoma treatment: Bcl-2 antisense therapy. Hospital Pharmacy Europe 14: 38-39, 2004.
  62. Campos EI, Martinka M, Mitchell DL, Dai DL, Li G. Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nuclear excision repair. Int. J. Oncol. 25:73-80, 2004.
  63. Campos EI, Xiao H, Li G. Generation of a polyclonal antibody specifically against the p33ING1b tumor suppressor. J. Immunoassay & Immunochem. 25: 71-80, 2004.
  64. Su M, Dorocicz I, Dragowska V, Ho V, Li G, Voss N, Gascoyne R, Zhou Y. Aberrant expression of T-plastin in Sezary cells. Cancer Res. 63: 7122-7127, 2003.
  65. Chin MY, Li G. Tissue-specific regulation of Chk2 expression by p53. Exp. Mol. Pathol. 75: 131-136, 2003.
  66. Dai D, Makretsov N, Campos EI, Huang C, Zhou Y, Huntsman D, Martinka M, Li G.  Increased expression of integrin-linked kinase is correlated with melanoma progression. Clin. Cancer Res. 9: 4409-4414, 2003.
  67. Bush JA, Li G. The role of Bcl-2 family members in the progression of cutaneous melanoma. Clin.  Exp. Metastasis 20: 531-539, 2003.
  68. Lo CK, Bush JA, Li G. Tissue-specific regulation of Apaf-1 expression by p53. Oncol. Reports 10: 1139-1143, 2003.
  69. Chen B, Campos EI, Crawford R, Martinka M, Li G. Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinomas. Int. J. Oncol. 22: 927-931, 2003.
  70. Luu Y, Li G. The p53-stabilizing compound CP-31398 does not enhance melanoma chemosensitivity. Anticancer Res. 23: 99-106, 2003
  71. Cheung KJ Jr., Li G. The tumour suppressor p33ING1 does not regulate migration and angiogenesis in melanoma cells. Int. J. Oncol. 21: 1361-1365, 2002.
  72. Luu Y, Li G. The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU. J. Invest. Dermatol. 119: 1207-1209, 2002.
  73. Cheung KJ Jr., Li G. p33ING1 enhances UVB-induced apoptosis in melanoma cells.  Exp. Cell Res. 279: 291-298, 2002.
  74. Bush JA, Li G. Tissue-specific regulation of the murine ABCB1 homologue by p53. Carcinogenesis 23: 1603-1607, 2002.
  75. Lin P, Bush JA, Cheung KJ, Li G. Tissue-specific regulation of murine Fas by p53. Int. J. Oncol. 21:261-264, 2002.
  76. Luu Y, Cheung KJ Jr, Bush JA, Li G. The p53-stabilizing compound, CP31398, induces apoptosis by activating the intrinsic mitochondrial/caspases-9 pathway. Exp. Cell Res. 276:214-222, 2002.
  77. Cheung KJ Jr., Li G. The tumour suppressor p33ING1 does not enhance camptothecin-induced cell death in melanoma cells. Int. J. Oncol. 20:1319-1322, 2002.
  78. Bush JA, Li G. Cancer chemoressistance: The relationship between p53 and multidrug transporters. Int. J. Cancer 98:323-330, 2002.
  79. Campos E, Cheung KJ, Li S, Li G. The novel tumour suppressor gene ING1 is overexpressed in melanoma cell lines. Br. J. Dermatol. 146:574-580, 2002.
  80. Bush J, Cheung KJ Jr., Li G. Curcumin-induced apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp. Cell Res. 271:305-314, 2001.
  81. Cheung K-J Jr, Li G. Tissue-specific regulation of Chk1 expression by p53. Exp. Mol. Pathol. 71, 156-160, 2001.
  82. Cheung KJ, Mitchell DL, Lin P, Li G. The novel tumour suppressor p33ING1 mediates repair of UV-damaged DNA. Cancer Res. 61:4974-4977, 2001.
  83. Cheung KJ, Li G. The tumor suppressor ING1: structure and function. Exp. Cell Res. 268:1-6, 2001.
  84. Bush J, Li G. Anchorage-independent growth of p53 knockout dermal fibroblast is reversed by wild-type p53. J. Cutan. Med. Surg. 5:18-24, 2001.
  85. Cheung KJ, Li G. The tumor suppressor ING1: structure and function. Exp. Cell Res. 268:1-6, 2001.
  86. Bush J, Li G. Anchorage-independent growth of p53 knockout dermal fibroblast is reversed by wild-type p53. J. Cutan. Med. Surg. 5:18-24, 2001.



04.21.12
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