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The Clinical Trials Unit does investigator-initiated and industry-sponsored clinical studies of new dermatologic therapies in human subjects. The unit covers the full spectrum of clinical studies from Phase One through Phase Four. Most studies are multi-center, and some are conducted only at UBC. The unit is part of the University of British Columbia and the Vancouver General Hospital. Clinical trials have been conducted previously on all of the major therapeutic areas of dermatology, including acne, psoriasis, eczema, warts, skin cancer, and hair disorders. There have also been medical clinical studies, surgical clinical studies, and cosmetic clinical studies.
In a scientifically rigorous environment, the following questions are answered in Clinical Trials:
- Is this new therapy safe?
- Is this new therapy effective?
- How much more effective is this new therapy than what is currently available?
- What’s the best way to use this new therapy?
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| Location |
| We are centrally located in Vancouver, British Columbia; approximately 20-30 minutes from Vancouver International airport, in The Skin Care Centre. |
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| Staff |
| Dr. Stuart Maddin is the Director of Clinical Trials at the Skin Care Centre. We are able to draw from our pool of nine faculty members at the Department of Dermatology and Skin Science, Faculty of Medicine, University of British Columbia. Our site further benefits from additional patient population from the approximately 30 part-time faculty dermatologists in the Greater Vancouver area. The facility is staffed with 3 full-time Clinical Research Coordinators and 1 part-time RN. |
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| Investigators |
| Dr. Jan Dutz |
Dr. Harvey Lui |
| Dr. Vincent Ho |
Dr. David McLean |
| Dr. Neil Kitson |
Dr. Jerry Shapiro |
| Dr. Brian Kunimoto |
Dr. Youwen Zhou |
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| Fields/Objectives of Clinical Research in Dermatology |
- Clinical evaluations for safety and efficacy
- Dose-determining studies
- Clinical Trials for OTC monograph
- Clinical Trials for prescription drugs
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| Therapeutic Areas of Clinical Research |
- Acne
- Aging/Photoaging
- AHA’s & Tretinoin
- Antimicrobials
- Antifungals
- Antihistamines
- Antipsoriatics
- Antirosacea agents
- Antivirals
- Corticosteroids
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- Hair Growth Stimulants
- Ichthyosis
- Moisturizers
- Monoclonal Antibodies
- Photodynamic Therapies
- Sunscreen Products
- Topical Anaesthetics
- Wound Healing Agents
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Facilities
We have a dedicated clinical trial facility that includes: underground parking for patients, a waiting room, 2 examination rooms, a monitor’s room (equipped with a telephone, internet connection and photocopier/printer), an administration office, a trial coordinators’ office, a secure supplies room for CRF storage, double-locking medication storage cupboards, refrigeration unit and a –40°C freezer for sample storage.
List of Current Clinical Trials - 2008
- Efficacy and safety of alefacept in combination with narrow-band UVB (nbUVB) compared to alefacept alone in subjects with moderate to severe chronic plaque psoriasis (AME-001) / Astellas Pharma Canada
- Calcipotriol Plus Hydrocortisone Ointment Compared with Tacalcitol Ointment in Patients with Psoriasis Vulgaris on the Face and on the Intertriginous Areas (LEO 80190-O22) / LEO Pharma A/S.
- PSUNRISE: A Multicenter, Open-label Study to Assess the Efficacy and Safety of Infliximab (REMICADE®) Therapy in Patients With Plaque Psoriasis Who Had an Inadequate Response to Etanercept (ENBREL®) (C0168Z04) / Centocor Inc.
- A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects with Moderate to Severe Chronic Plaque Psoriasis (M06-890) / Abbott Laboratories Ltd.
- A Phase 3, Multicenter, Open-Label Continuation Study in Moderate to Severe Chronic Plaque Psoriasis Subjects who Completed a Preceding Psoriasis Study With ABT-874 (M10-016) / Abbott Laboratories Ltd.
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09.28.11 |
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