The skin as a site of initiation of systemic autoimmune disease: new opportunities for treatment.

Dutz JP.

Dendritic cells are the coordinators of the adaptive immune response. Chronic activation of skin dendritic cells by keratinocyte expression of CD40 ligand (CD40L; CD154) leads to autoimmunity. In this issue, systemic administration of tacrolimus is shown by Loser et al. to effectively treat autoimmunity in a murine model involving transgenic keratinocyte expression of CD40L.

J Invest Dermatol. 2006 Jun;126(6):1209-12.

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