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Created: 30Dec97
Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: A clinical and immunopathologic evaluation
Jerry Shapiro, MD, FRCPC, Harvey Lui, MD, FRCPC, Victor Tron, MD, FRCPC, and Vincent Ho, MD, FRCPC
First Paragraphs: Cyclosporine is widely used as an immunomodulatory agent. One of its most common side effects is dose-dependent hypertrichosis, which affects 80% of patients. Hypertrichosis is usually noted approximately 8 weeks after initiation of therapy and slowly resolves after treatment. The development of hypertrichosis is not hormone-induced, but is possibly caused by a direct effect of the drug on hair growth.
Cyclosporine has been used in the treatment of alopecia areata (AA) with varying success. Topical cyclosporine has generally been unsuccessful. However, systemic cyclosporine has been beneficial in chronic severe AA.
J Am Acad Dermatol 1997;36:114-7
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